| Title | Postdoctoral Fellow |
|---|---|
| School | Harvard T.H. Chan School of Public Health |
| Department/Area | Department of Immunology and Infectious Diseases |
| Position Description | The Le Pen Lab at the Harvard T.H. Chan School of Public Health (HSPH) is seeking a Postdoctoral Fellow to join our research on innate immunity to RNA viruses. The position is funded by the NIH Directors New Innovator Award (DP2), Next-Generation Interferons: Mapping and Engineering Antiviral Function (NIAID, 20262031). (https://hsph.harvard.edu/research/le-pen-lab/). Our Research We seek to explain a fundamental paradox in human disease: why common viral infections cause little harm in most individuals yet lead to life-threatening or chronic disease in others. We investigate the cell-intrinsic mechanisms of innate immunity that enable cells to detect viruses, limit infection, and resolve immune activation once the pathogen has been cleared. We focus on long-lived, irreplaceable cell types such as neurons and pancreatic cells, which, unlike epithelial cells, must survive infection while keeping their specialized functions. Two questions organize the work:
The DP2 project Interferon fails in opposite directions: too weak, and ordinary viruses become lethal; too strong or too prolonged, and it drives inflammatory and autoimmune diseases. The project attempts to uncouple the wanted and the undesired effects of interferon, combining human genetics, functional screening and cell biology. The fellow will take on a substantial part of this program, with scope to develop a research direction that is original but fits the aims of the award and the priorities of the group. The environment
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| Basic Qualifications |
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| Additional Qualifications |
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| Special Instructions | |
| Contact Information | Email Jrmie Le Pen at jlepen@hsph.harvard.edu with a CV, a letter of interest, and the names, email addresses and relationship to you of at least three references, one of whom should be your PhD supervisor. |
| Contact Email | jlepen@hsph.harvard.edu |
| Salary Range | PGY | Salary 0 | $70,000 1 | $72,100 2 | $74,263 3 | $76,491 4 | $78,786 5 | $81,149 6 | $83,583 7+ | $86,091 |
| Minimum Number of References Required | 3 |
| Maximum Number of References Allowed | |
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PI287904238
